Restylane Lift®: The First and Only FDA-Approved Filler for Plumping Your Cheeks and Erasing Your Smile Lines

Restylane Lift®: The First and Only FDA-Approved Filler for Plumping Your Cheeks and Erasing Your Smile Lines
Restylane Lift®: The First and Only FDA-Approved Filler for Plumping Your Cheeks and Erasing Your Smile Lines

It’s official: we live in a facial contouring-crazed society and right now, it’s all about sculpted, high cheekbones, full lips and a defined jawline. Normally, it would take hours of makeup application to achieve this look – and almost as long to remove the numerous cosmetic layers, but now you can plump up with dermal filler instead. Restylane Lyft (formerly branded as Perlane), was approved last month by the FDA to increase volume in the cheek area and smooth out nasolabial folds. It is an injectable gel and the first and only FDA-approved treatment for these concerns. We recently caught up with Chicago-area based plastic surgeon, Dr. Laurie Casas to learn all about what you need to know before you give it a go, and how it can make hollow cheekbones and smile lines a thing of the past.

Dr. Casas says Restylane Lyft is recommended for patients over the age of 21 with contour deformities in their cheeks from volume loss due to aging or weight loss. “Restylane Lyft with Lidocaine can also be used to correct moderate to severe facial folds like the nasolabial folds, commonly known as the smile lines,” she explains. “The injection technique is different for these areas.”

Who should avoid it? “Those with severe allergies that require in-hospital treatment, those with lidocaine allergies and people with bleeding disorders should not use Restylane Lyft,” cautions Dr. Casas.

The pain level is minimal because of the lidocaine, a local anesthetic that causes temporary numbness. The procedure on both cheeks costs about $1,200 - $3,000, depending on how many 1cc syringes are needed to correct the cheek volume loss.” The number of sessions required to achieve the desired result will also depend on the volume deficit.

What results can you expect from this treatment? “In a clinical trial involving 200 patients, investigators observed that 88.7% of patients treated with Restylane Lyft showed an improvement in fullness in the right and left midface areas (combined) at 2 months, and more than half maintained improvement for 12 months. Additionally, 95% of patients reported improvement with the appearance of their midface at 2 months and 73% of patients reported improvement at 12 months. The most common adverse events observed in the trial included: tenderness, redness, bruising, swelling and itching. These events decreased in severity over time and most were resolved within 2 weeks. While Restylane Lyft is the first and only FDA-approved filler indicated to provide fullness to the midface area (cheeks) and to correct and smooth the nasolabial folds, it can also be used off-label on the temples. Dr. Val Lambros wrote about a technique Dr. Casas uses off-label to plump up hollow temples, a common sign of aging which makes the face appear “pinched” and brows look shorter. Dr. Casas dilutes the Restylane Lyft with saline and injects it into the temple for volume restoration. As the saline component absorbs, the filling material is distributed more evenly in the temple than with undiluted filler. The results from applying this technique last approximately two to three years.

Can Restylane Lyft be injected at the same time as other injectables? Restylane Lyft can be combined with Botox and other injectables; however, Dr. Casas notes that they perform different functions. “Neurotoxins like Botox, Dysport and Xeomin are used for correction of fine lines due to muscle activity in the periorbital area, like between the eyebrows and crow’s feet, while Restylane Lyft is administered to increase volume in the midface smoothing out wrinkles too.”

Adding volume to the midface region might require fillers to be injected into the temple and forehead to balance out a patient’s facial features. There are several FDA-approved dermal fillers on the market today enabling aesthetic plastic surgeons to customize treatments targeting various facial zones using different dermal fillers indicated for each respective area to produce natural-looking results with a longer shelf-life. Consult with a board-certified plastic surgeon in your area to determine what fillers will help you achieve your overall desired look.

About the Author

Amber Katz is a freelance writer, consultant, copy writer/editor and founder of, a pop culture-infused beauty blog featuring everything from skin smoothers to hair spray to body scrubs. A former financial copy writer, Amber started her blog in 2006 as an outlet from which to rave about her favorite lotions and potions to fellow beautyphiles—instead of her non-target audience of middle-aged (straight) male auditors at the office. Amber writes frequently for,, and Yahoo Beauty.